ImmunoGen TAP Technology Receives Endorsement from Novartis through Collaboration Agreement

ImmunoGen, Inc. announced on Monday 10/11 that it has entered into a collaboration agreement with Novartis to discover and develop targeted anticancer therapeutics using antibodies to several antigen targets to be named by Novartis.
Novartis will pay a $45 million upfront fee to ImmunoGen for exclusive rights to the Targeted Antibody Payload (TAP) technology with antibodies to a specified number of antigen targets. ImmunoGen is also entitled to receive milestone payments plus royalties on product sales for each target resulting in an anticancer therapeutic.
A TAP compound consists of a tumor-targeting manufactured antibody with one of ImmunoGen’s proprietary, highly potent cancer killing agents attached as a payload. The antibody serves to deliver the payload specifically to tumor cells, and the payload serves to kill these cells. Essentially it is as if a bomb is sent into the tumor, and explodes inside, killing the cancer cells, but preserving the surrounding tissue. The objective is more targeted delivery of chemotherapy and subsequently lower side effects. Described in a different way, the Company's proprietary TAP, technology combines extremely potent small molecule cytotoxic agents with monoclonal antibodies that bind specifically to cancer cells. The Company's TAP technology is designed to increase the potency of tumor-targeting antibodies and kill cancer cells with only modest damage to healthy tissue.
There are currently seven TAP compounds in the clinic, with a wealth of clinical data reported with the technology. ImmunoGen collaborative partners include Amgen, Bayer Schering Pharma, Biogen Idec, Biotest, Genentech (a member of the Roche Group), Sanofi-Aventis, and now Novartis. The most advanced compound using ImmunoGen's TAP technology, T-DM1, is in Phase III testing through the Company's collaboration with Genentech (as highlighted in our prior blog).
For more information about ImmunoGen you can view the comapany website: http://www.immunogen.com/wt/home/home
For the specific press release about the Novartis agreement click here.

Roche’s Drug T-DM1 for Breast Cancer – Phase II Results are “Stunning”

In advance of the oncology conference of the ESMO (European Society for Medical Oncology) in Milan on Monday, Severin Schwan, Chief Executive Officer of Roche Holding AG announced his opinion that the data from the Phase II trial for T-DM1 was “stunning.” T-DM1is in clinical trials for breast cancer. It is the first of a new kind of “armed antibody” that can carry a cell-killing payload into cancer cells. The drug is being developed with partner ImmunoGen. T-DM1’s results were better than than that of Herceptin plus Taxotere. In addition, clinically adverse side effects were lower.
Herceptin, also a Roche drug, and currently has sales of about $5 billion annually.
More details will be released this week.

T-DM1 has advanced to Phase III testing.
For further details about this press information from Reuters please click here.

For products that can help alleviate unpleasant side effects from current breast cancer treatments including radiation and chemotherapy please view our website www.LotsToLiveFor.com

Celldex Brain Cancer Vaccine Update – More Good News on Immunotherapy

The Celldex Therapeutics Inc. vaccine brain cancer received an encouraging result according to US Researchers. Patients with the brain cancer glioblastoma who were treated with this vaccine lived nearly twice as long as those who received radiation and chemotherapy.

This type of cancer often kills patients within a year; patients rarely survive more than three years. In this study, many patients are still alive after five years.

The Celldex Therapeutics Inc. vaccine works by targeting a mutation in a gene called the epidermal growth factor receptor, which fuels cancer growth.

The results were published in the Journal of Clinical Oncology online. Researchers contributing to the study were Dr. John Sampson of Duke University in conjunction with researchers from the University of Texas MD Anderson Cancer Center.

To read more about this study access the article on Thompson Reuters here.
http://www.msnbc.msn.com/id/39505662/ns/health-cancer/

You can also refer to The Journal of Clinical Oncology here.
http://jco.ascopubs.org/

For products to help alleviate unpleasant and uncomfortable side effects of radiation and chemotherapy treatment, please click here.
http://www.LotsToLiveFor.com

Salmonella Bacteria May Help Trigger Immune Response to Cancer Cells

Scientists have discovered that treating tumors with salmonella bacteria can induce an immune response that kills cancer cells, scientists have found -- a discovery that may help them create tumor-killing immune cells to inject into patients.

Researchers from Italy and the United States who worked with mouse and human cancer cells in laboratories said their work might help in developing a new drug in a class of cancer treatments called immunotherapies or therapeutic vaccines, which harness the body's immune system to fight disease.

To read the full article from abc news that this short abstract was excerpted from click here.

The full study was published in the journal Science Translational Medicine on Wednesday 8/11/10.